What is
Regenerative Cell Therapy?

Regenerative therapy or regenerative cellular medicine is the practice of creating functional and living tissues to restore and replenish organ or tissue function otherwise irrecoverable because of inherent frailty, damage, age, or disease. Physicians have seen success utilizing these alternative therapies in various medical areas. Theses cutting-edge regenerative options give patients alternative solutions to surgery or traditional medical treatments.

The centric practice of regenerative therapy is the involvement of cathartic cells for improved tissue and organ function. Adult therapeutic cells have several distinctions: Autologous cells, Allogeneic cells, Homologous cells, Non-homologous cells.

  • Autologous cells – derived from the patient

  • Allogeneic cells – taken from another individual

  • Homologous cells – derived from the same organ or tissue to which they are being used

  • Non-homologous cells – comes from a tissue or organ not the same as the one receiving the application

Types of Regenerative Therapy

Allograft

Allografts are tissue transplants that are allogeneic in nature. This essentially is live tissue transplant from one entity to another from the same species – i.e. human to human. Allograft are derived from birthing tissue allograft which is obtained from C-section deliveries.

Physicians utilizing this therapy in their treatment protocols have seen tremendous improvements in restoring normal functionality for the patient suffering from injury related medical conditions.

Amniotic

Stem cells derived from amniotic fluid are considered an ideal resource for therapy due to their high capability for renewal. Amniotic stem cells can supplement or replace damaged or inadequate connective tissue. Amniotic fluid is extremely condensed in proteins, cytokines, cells (stem) and other significant compounds, leading to its high healing potential. This nutrient rich source fluid can minimize scars and inflammation and are naturally regenerative.

Umbilical

The umbilical cord blood has a rich supply of cells (stem) that can help generate immune system cells and blood cells. This blood is obtained from the umbilical cord of newborns. Currently, umbilical cord-derived stem cells are used for treating conditions such as leukemia and autoimmune diseases. Mesenchymal stromal cells can also be obtained from the blood of the umbilical cord.

Wharton’s Jelly

Wharton’s jelly is a coagulated tissue, from the umbilical cord, which contains a population of mesenchymal stromal cells within the umbilical cord. This clear, gel-like tissue insulates and protects the umbilical arteries and veins. Wharton’s Jelly encompasses a higher concentration of hyaluronic acid and growth factors, in comparison to amniotic fluid.

The Wharton’s jelly-derived cells are transplantable cells that can be used to potentially treat many diseases, such as liver disease, cancer, cardiovascular diseases and nerve injury. These cells aim to supplement or replace damaged or inadequate connective tissue.

Allografts work well as a standalone treatment options or as an extracellular matrix (EMC) additive to Platelet Rich Plasma (PRP). When combined with PRP, allografts works as a supercharger, improving its lasting effect for longer and better results.

Adipose

Adipose Derived Stem Cells (ADSC) aka Cell Rich Fat Transfer:

Adipose-derived stem cells are a type of mesenchymal stem cell that is derived from
fat tissue. Adipose-derived stem cell are obtained from abundant adipose tissue and
have the ability of self-renewal and multi-potential differentiation.
Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF)
cells. This autologous therapy is effective for the repair and regeneration of acute
chronically damaged tissue.

Stromal Vascular Fraction (SVF):

Stromal Vascular Fraction (SVF) is the primary source of adipose-derived
mesenchymal stem cells. SVF of adipose tissue is a rich source of mesenchymal stem
cells, preadipocytes (undifferentiated fibroblasts) and other cell types.

When the adipose tissue is harvested, the final product is called stromal vascular
fraction. SVF is a component of the lipoaspirate (removing fat from the human body) accessed from the liposuction of excess adipose tissue.

Platelet Rich Plasma (PRP)

Platelet Rich Plasma is an alternative therapy that uses your own blood to promote healing and repair to damaged or injured tissues in the body. PRP therapy is autologous in nature which minimizes risk to patients as they are using their own blood. Risk of treatment rejection or negative reaction is mostly non-existent. This therapy helps to initiate the regenerative process by utilizing the growth factors that are contained in platelets.

Platelets play an important role in the body’s ability to heal soft tissue and wounds. As the body has a great ability to heal itself, re-injecting concentrated platelets serves to enhance the healing process.

The PRP procedure entails the following: A blood sample is taken from a patient and placed into a centrifuge which separates the blood. Once the blood is divided into its separate components, the platelet rich component is introduced into an injured soft tissue. From activated platelets and after injection into the abnormal tissue, mesenchymal cells are proliferated in the tissue from growth factors that were released.

Bone Marrow

Autologous bone marrow therapy is gaining traction as a viable alternative for treating patients whose bone marrow or immune system is damaged.

Marrow is soft tissue within your bones that aides in the production of blood forming cells. Blood forming cells are undeveloped cells that propagate into red and white cells or platelets. Mostly, hematopoietic stem cells are found in bone marrow.

There are 3 types of bone marrow transplants:

  • Autologous bone marrow transplant

  • Allogenic bone marrow transplant

  • Umbilical cord blood transplant

Donor stem cells can be collected in two ways:

  • Bone marrow harvest

  • Leukopheresis