Despite significant advances in medical and device therapy over the past decades, chronic heart failure (HF) represents an increasingly common and debilitating disorder worldwide. Even in the 21st century, HF carries a dismal prognosis and is related to unacceptably high mortality rates. Although current HF treatment options have been shown to improve HF symptoms and signs, to reduce heart failure-related hospital admissions, and above all to improve patients’ survival, no therapeutic modality to date has addressed the repair of damaged/lost myocardial tissue.

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