The anterior cruciate ligament (ACL) is one of the most studied structures of the human musculoskeletal system, being the subject of many anatomic and biomechanical studies. [pdf-embedder url="https://www.nsorm.com/wp-content/uploads/2018/07/PRP-and-Stem-Cells-in-Partial-ACL-Tears-Jan-2017.pdf" title="PRP and Stem Cells in Partial ACL Tears Jan 2017"]
Chronic musculoskeletal diseases, such as tendinopathy, are largely refractory to therapy. Healing capabilities are restricted because of the acellular, aneural, and avascular nature of tendons. [pdf-embedder url="https://www.nsorm.com/wp-content/uploads/2018/07/PRP-and-BM-MSCs-in-Tendon-Healing-Feb-2017.pdf" title="PRP and BM-MSC's in Tendon Healing Feb 2017"]
A normal healing response after ligament and tendon rupture results in scar formation and an inferior tissue that fails to emulate its original structure, composition, and function. More regenerative healing (closer to the original) can be obtained through early suppression of inflammatory cells and associated cytokines [pdf-embedder url="https://www.nsorm.com/wp-content/uploads/2018/07/MSCs-in-Tendon-Ligament-Healing.pdf" title="MSC's in Tendon-Ligament Healing"]
Patellar tendinosis (PT) is a clinical syndrome characterised by anterior knee pain and tenderness at the insertion of the patellar tendon on the inferior pole of the patella. Commonly known as “jumper’s knee”, PT causes pain following repetitive running or jumping exercises, which usually settles with rest but returns when exercise is recommenced). [pdf-embedder url="https://www.nsorm.com/wp-content/uploads/2018/07/PRP-in-Tx-of-Refractory-Patellar-Tendinosis-Sept.-2017.pdf" [...]
In Greek mythology, Achilles, the demigod hero, is almost invulnerable except for his Achilles heel, whose injury resulted in his death. How could a tendon injury take such a prominent place in Greek mythology? This injury was obviously such a crucial and inexplicable event that it was extensively honored in the legendary Iliad of Homer. [...]